Course Overview: This course explores specialized topics in bioinorganic chemistry, focusing on the synthesis, characterization, and applications of bioactive molecules and transition metal complexes, particularly those designed for cellular imaging, anticancer photodynamic therapy, and photoredox catalysis. Emphasis will be on understanding the role of metal ions in biological systems and how these principles can be harnessed in therapeutic and diagnostic settings.
Learning Objectives:
Understand the principles of bioinorganic chemistry as they relate to cellular imaging and therapeutic applications.
Develop proficiency in synthesizing bioactive and fluorophore-appended transition metal complexes.
Gain hands-on experience in characterizing metal complexes and ligands using spectroscopic techniques.
Explore the mechanisms of photodynamic therapy and photoredox catalysis.
Topics Covered:
Introduction to Coordination Chemistry, Bioinorganic Chemistry
Overview of metal ions in biological systems
Fundamental principles of coordination chemistry
Synthesis of Transition Metal Complexes
Strategies for designing bioactive complexes
Fluorophore conjugation for imaging applications
Characterization Techniques
Nuclear Magnetic Resonance (NMR) Spectroscopy: Analyzing ligand environments and metal coordination
Infrared (IR) Spectroscopy: Functional group analysis
UV-Visible (UV-Vis) Spectroscopy: Electronic transitions and complex stability
Emission Studies: Photophysical properties for imaging applications
Assessment Methods:
Quizzes: 2-3 quizzes to assess foundational knowledge.
Literature Review Presentation: Students will present a selected paper, analyzing the approach, results, and relevance to course themes.
Project Proposal: A written proposal on a bioinorganic chemistry topic focusing on novel applications in cellular imaging or PDT.
Lab Reports: Based on hands-on spectroscopic characterizations conducted in class.
Course Schedule:
Lectures: Twice weekly (55 MIN each session)
Office Hours: By appointment
Required Materials:
Textbook: Selected readings from Principles of Bioinorganic Chemistry and relevant research papers.
Software: Access to spectroscopic analysis tools (provided by the Haverford/Lab).
Additional Notes: This seven-week quarter course is intended for advanced undergraduate students. Based on class progress, adaptations may occur.
Learning Objectives:
Understand the principles of bioinorganic chemistry as they relate to cellular imaging and therapeutic applications.
Develop proficiency in synthesizing bioactive and fluorophore-appended transition metal complexes.
Gain hands-on experience in characterizing metal complexes and ligands using spectroscopic techniques.
Explore the mechanisms of photodynamic therapy and photoredox catalysis.
Topics Covered:
Introduction to Coordination Chemistry, Bioinorganic Chemistry
Overview of metal ions in biological systems
Fundamental principles of coordination chemistry
Synthesis of Transition Metal Complexes
Strategies for designing bioactive complexes
Fluorophore conjugation for imaging applications
Characterization Techniques
Nuclear Magnetic Resonance (NMR) Spectroscopy: Analyzing ligand environments and metal coordination
Infrared (IR) Spectroscopy: Functional group analysis
UV-Visible (UV-Vis) Spectroscopy: Electronic transitions and complex stability
Emission Studies: Photophysical properties for imaging applications
Assessment Methods:
Quizzes: 2-3 quizzes to assess foundational knowledge.
Literature Review Presentation: Students will present a selected paper, analyzing the approach, results, and relevance to course themes.
Project Proposal: A written proposal on a bioinorganic chemistry topic focusing on novel applications in cellular imaging or PDT.
Lab Reports: Based on hands-on spectroscopic characterizations conducted in class.
Course Schedule:
Lectures: Twice weekly (55 MIN each session)
Office Hours: By appointment
Required Materials:
Textbook: Selected readings from Principles of Bioinorganic Chemistry and relevant research papers.
Software: Access to spectroscopic analysis tools (provided by the Haverford/Lab).
Additional Notes: This seven-week quarter course is intended for advanced undergraduate students. Based on class progress, adaptations may occur.
- Teacher: Md Kausar Raza
- Teacher: Joseph Smith